Protein similarity

Research project Protein similarity

Determining similarity between proteins in biophysical space.

We are exploring how we can use our approaches to improve the detection of protein function and homology in their 'biophysical' instead of their sequence space.

Funding

G.0328.16N (Jan. 1, 2016-Dec. 31, 2019)
FoldMod - The role of local amino acid interactions in the folding of proteins, the stability of their fold and the location of post-translational modifications.

O&O project with Confo therapeutics (Jan. 1, 2023-Dec. 31, 2024)
We receive funding from this O&O project to connect our tools to inside approaches at <a href="https://www.confotherapeutics.com">Confo Therapeutics</a> to help with the <i>in silico</i> screening of new target proteins.

FWO-SB (Nov. 1, 2022-Oct. 31, 2026)
FWO-SB grant to Charlotte Crauwels to work on the design of hybrid GPCRs

Resources

Rigapollo (Software tool, In-house)

ST resource  Rigapollo
Rigapollo is an SVM-dependent pairwise HMM tool for protein pairwise alignments.