Protein design

Research project Protein design

Using computation to pre-screen the vast protein sequence space.

Due to the complexity of proteins it is not easy to (re-)design them. In collaboration with experimentalists, we employ our prediction approaches to 'filter' the available protein sequence space, so increasing the chance that the experiments will find a functional 'hit'. For example, in synthetic biology we are trying to crack how RNA Recognition Motifs (RRMs) work in order to design RRMs with specific RNA binding.


G.0328.16N (Jan. 1, 2016-Dec. 31, 2019)
FoldMod - The role of local amino acid interactions in the folding of proteins, the stability of their fold and the location of post-translational modifications.


No resources associated yet with this research project.